Week One Spreads
The favorites are listed in
Bold with the number of points they are favored by after their name.
| Date |
Kickoff Time (CT) |
Visitor |
Home |
| 09/07/2023 | 7:20 PM | Detroit | Kansas City -4½ |
| 09/10/2023 | 12:00 PM | Carolina | Atlanta -3½ |
| 09/10/2023 | 12:00 PM | Cincinnati -2½ | Cleveland |
| 09/10/2023 | 12:00 PM | Jacksonville -4½ | Indianapolis |
| 09/10/2023 | 12:00 PM | Tampa Bay | Minnesota -5½ |
| 09/10/2023 | 12:00 PM | Tennessee | New Orleans -2½ |
| 09/10/2023 | 12:00 PM | San Francisco -2½ | Pittsburgh |
| 09/10/2023 | 12:00 PM | Arizona | Washington -6½ |
| 09/10/2023 | 12:00 PM | Houston | Baltimore -9½ |
| 09/10/2023 | 3:25 PM | Green Bay | Chicago -½ |
| 09/10/2023 | 3:25 PM | Las Vegas | Denver -3½ |
| 09/10/2023 | 3:25 PM | Philadelphia -3½ | New England |
| 09/10/2023 | 3:25 PM | Miami | L.A. Chargers -2½ |
| 09/10/2023 | 3:25 PM | L.A. Rams | Seattle -5½ |
| 09/10/2023 | 7:20 PM | Dallas -3½ | N.Y. Giants |
| 09/11/2023 | 7:15 PM | Buffalo -2½ | N.Y. Jets |